Program Schedule

Updated as of 4 Jan 2016

Dates: 4 - 8 January, 2016

4 Jan | 5 Jan | 6 Jan | 7 Jan | 8 Jan

4 Jan 2016 (Mon)

Time Event
Session 1: Structural Basis of Transcription [chair: Robert Landick]
08:30-09:00 Registration (* Shuttle bus pick-up from Holiday Inn Express at 08:30)
09:00-09:20 Opening Remarks
09:20-10:00 “Structural Basis of RNA Polymerase II Initiation”
Patrick Cramer (The Max Planck Institute for Biophysical Chemistry)
10:00-10:40 “Using the Time-Resolved X-Ray Crystallography to Monitor Nucleic Acid Polymerases Choose Right from Wrong”
Katsuhiko Murakami (Pennsylvania State University)
10:40-11:10 Coffee break
11:10-11:50 “Structural Studies on RNA Polymerase I”
Carlos Fernández Tornero (The Spanish National Research Council (CSIC))
11:50-12:30 “Structure of an RNA Polymerase II Preinitiation Complex”
Kenji Murakami (University of Pennsylvania)
12:30-14:00 Lunch (for registered participants only)
Session 2: Mechanism and Modeling [chair: Dong Wang]
14:00-14:40 “Simulations of Pol II Transcription Elongation Mechanisms”
Xuhui Huang (The Hong Kong University of Science and Technology)
14:40-15:20 “Investigation of Transcription Elongation Factors in RNA Polymerase Dynamics”
Toyotaka Ishibashi (The Hong Kong University of Science and Technology)
15:20-16:00 “NTP Entry and Fidelity in RNA Polymerase II from Computer Simulations”
Michael Feig (Michigan State University)
16:00-16:30 Coffee break
16:30-17:10 “Mapping the Distinct Configurations of Nucleic Acids in Transcription Complexes by Kinetic and Biophysical Methods”
Georgi Belogurov (University of Turku)

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5 Jan 2016 (Tue)

Time Event
Session 3: Initiation/ Mechanisms [chair: Xuhui Huang]
09:00-09:40 “Structural Studies of Bacterial Transcription”
Seth Darst (The Rockefeller University)
09:40-10:20 “Mediator-Dependent Activation of the PIC”
Sohail Malik (The Rockefeller University)
10:20-10:50 Coffee break
10:50-11:30 “The Mechanism of Initial DNA Unwinding in Eukaryotic Transcription”
Eric Galburt (Washington University in St. Louis)
11:30-12:10 “Structural and Biochemical Studies of Mycobacterial Specific Transcription Factors”
Elizabeth Campbell (The Rockefeller University)
12:10-14:00 Lunch (for registered participants only)
14:00-18:30 Free time (boat trip for invited participants)

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6 Jan 2016 (Wed)

Time Event
Session 4: Elongation/ Regulation [chair: Joan Conaway]
09:00-09:40 “Genome-wide Views of the Mechanisms of Transcriptional Regulation”
John Lis (Cornell University)
09:40-10:20 “Gene Expression Control by RfaH”
Irina Artsimovitch (The Ohio State University)
10:20-10:50 Coffee break
10:50-11:30 “Overcoming Barriers to RNAPII Transcription”
Joseph Reese (Pennsylvania State University)
11:30-12:10 “Modeling Fluctuation and Control in Transcription Elongation from T7 RNA Polymerase to Polymerase II”
Jin Yu (Beijing Computational Science Research Center)
12:10-14:00 Lunch (for registered participants only)
Session 5: Coupling of Transcription Elongation and DNA Damage Processing [chair: David Price]
14:00-14:40 “Mechanism of Polymerase II Transcription Elongation and DNA Modification Recognition”
Dong Wang (University of Wisconsin-Madison)
14:40-15:20 “Elongin and the Elongin A Ubiquitin Ligase Complex in Transcription and the Response to DNA Damage”
Joan Conaway (Stowers Institute for Medical Research)
15:20-15:50 Coffee break
15:50-16:30 “The Transcription-Related DNA Damage Response”
Jesper Svejstrup (The Francis Crick Institute)
16:30-17:10 “New Principles of Transcription-Coupled DNA Repair”
Evgeny Nudler (New York University)
17:10-17:50 “Signatures of Replication-Transcription Conflicts in Bacteria”
Jade Wang (University of Wisconsin-Madison)
18:00-20:30 Dinner banquet (by invitation only)

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7 Jan 2016 (Thu)

Time Event
Session 6: Genome-scale Transcription [chair: Jesper Svejstrup]
09:00-09:40 “Transcription in the Archaea - From Molecules to Systems”
Finn Werner (University College London)
09:40-10:20 “Roles of Cohesin in Regulating Genome Structure and Function during Active Transcription”
Xin Liu (University of Texas Southwestern Medical Center)
10:20-10:50 Coffee break
10:50-11:30 “Molecular Features of Chromatin Modifiers that Travel with Elongating RNA Polymerase II”
Bing Li (University of Texas Southwestern Medical Center)
11:30-12:10 “Nuclear Walk - On the Wild Side”
David Price (University of Iowa)
12:10-14:00 Lunch (for registered participants only)
Session 7: Mechanisms of Transcription II [chair: Irina Artsimovitch]
14:00-14:40 “Mechanism and Regulation of Transcriptional Pausing”
Robert Landick (University of Wisconsin-Madison)
14:40-15:20 “Experimental and Theoretical Approaches to Study Molecular Machines Involved in Transcription”
Robert Weinzierl (Imperial College London)
15:20-15:50 Coffee break
15:50-16:30 “Mechanisms of Catalysis and Regulation in Viral RNA-Dependent RNA Polymerases”
Peng Gong (Wuhan Institute of Virology, Chinese Academy of Sciences)
16:30-17:10 “Fundamental Understandings from a Model RNA Polymerase”
Craig Martin (University of Massachusetts Amherst)
17:10-17:20 Jianfei Zhao (Nature Communications)
17:20-17:35 Closing Remarks

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8 Jan 2016 (Fri)

Time Event
  IAS Distinguished Lectures (Location: IAS Lecture Theater, G/F)
14:30-16:00 “Structural Biology of Bacterial Transcription: Electron Microscopy to X-ray Crystallography and Back Again” [Details]
Seth Darst (The Rockefeller University)
16:00-17:30 “Genome-wide Views of the Mechanisms of Transcriptional Regulation” [Details]
John Lis (Cornell University)

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Venue

IAS 4042, 4/F, Lo Ka Chung Building, Lee Shau Kee Campus, The Hong Kong University of Science & Technology
 



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